Read the following passage and mark the letter A, B, C, or D on your answer sheet to indicate the correct word or phrase that best fits each of the numbered blanks from 46 to 50.

     Amy Tan was born on February 19, 1952 in Oakland, California. Tan grew up in Northern California, (46) _____ when her father and older brother both died from brain tumors in 1966, she moved with her mother and younger brother to Europe, where she attended high school in Montreux, Switzerland. She returned to the United States for college. After college, Tan worked as a language development consultant and as a corporate freelance writer. (47) _____ 1985, she wrote the "Rules of the Game” for a writing workshop, which laid the early foundation for her first novel The Joy Luck Club. Published in 1989, the book explored the (48) _____ between Chinese women and their Chinese-American daughters, and became the longest running New York Times bestseller for that year. The Joy Luck Club received numerous awards, including the Los Angeles Times Book Award. It has been translated into 25 languages, including Chinese, and was made into a major motion picture for (49) _____ Tan co-wrote the screenplay. Tan's (50) _____ works have also been adapted into several different forms of media.